amyloid precursor protein
- amyloid precursor protein
-
Individuals with Alzheimer\'s disease are characterized by extensive accumulation of
amyloid in the brain, referred to as senile plaques. These consist of
a core of
amyloid fibrils surrounded by dystrophic neurites. The principal component of the
amyloid fibrils is B/A4,
a peptide derived from the larger APP. The specific role of
amyloid protein is unclear but it is thought that
amyloid deposits may cause neurons to degenerate. Amyloid deposits also occur in brains of older Down\'s Syndromepatients.
Dictionary of molecular biology.
2004.
Look at other dictionaries:
Amyloid precursor protein — (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formationPriller C, Bauer T, Mitteregger G,… … Wikipedia
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Beta amyloid — protein Name = amyloid beta (A4) precursor protein (peptidase nexin II, Alzheimer disease) caption = Processing of the amyloid precursor protein width = 300 HGNCid = 620 Symbol = APP AltSymbols = AD1 EntrezGene = 351 OMIM = 104760 RefSeq = NM… … Wikipedia
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